Textbook of Medical Biochemistry 3rd edition by Dinesh Puri – Ebook PDF Instant Download/Delivery. 8131238059, 9788131238059
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ISBN 10: 8131238059
ISBN 13: 9788131238059
Author: Dinesh Puri
The third edition of the book is thoroughly updated and presented in a new two-colour format. The book presents a detailed and authoritative exposition of the basic principles and applications of biochemistry. It focuses primarily on clarity of the fundamental concepts and explains them according to the need of undergraduate medical students. The organization of content in this book is such that it provides the reader with a logical sequence of events that aids learning.
- More emphasis in this edition is to systemize presentation and make reading soothing and pleasurable by deleting redundant details, adding new text and figures, improvement of earlier figures, supplementing text with easy to comprehend flowcharts, without changing basic framework of the book.
- Each chapter ends with clinical cases and the related questions, which evokes yet another method of active learning rather than didactic methods of imparting knowledge.
- Key points have been highlighted and boxed at the end of each topic for quick revision of the core concepts.
- This book comes with a free companion website which contains self-assessment exercises, detailed case discussions related to the clinical cases given inside the book, glossary and various other features for enhanced learning.
Textbook of Medical Biochemistry 3rd Table of contents:
Chapter 1: Water
- I. Water as Principal Biological Fluid
- II. Acids, Bases, and Conjugate Acid-Base Pairs
- III. Acid-Base Balance: Applied Aspects
- Exercises
Chapter 2: Chemistry of Carbohydrates
- I. Biological Significance of Carbohydrates
- II. Classification of Carbohydrates
- III. Structural Properties
- IV. Hexoses, Pentoses, and Related Disaccharides and Oligosaccharides
- V. Derived Sugars
- VI. Polysaccharides
Chapter 3: Chemistry of Lipids
- I. Fatty Acids
- II. Classification of Lipids
Chapter 4: Amino Acids
- I. Amino Acids
- II. Peptides
- III. Proteins
- IV. Chemical Synthesis of Proteins
Chapter 5: Proteins with Biological Activity
- I. Collagen
- II. Elastin
- III. Glycoproteins
- IV. Plasma Proteins
- V. Immunoglobulins
Chapter 6: Enzymes
- I. Properties of Enzymes
- II. Mechanism of Enzyme Catalysis
- III. Nomenclature
- IV. Quantitative Assay of Enzymes
- V. Enzyme Kinetics
- VI. Michaelis–Menten Kinetic Theory of Enzyme Action
- VII. Inhibition of Enzyme Activity
- VIII. Regulation of Enzyme Activity
- IX. Isoenzymes
- X. Enzymes in Clinical Diagnosis
- XI. Enzymes as Therapeutic Agents
Chapter 7: Characteristics of Cells and Membrane Transport
- I. Cell Structure
- II. Biological Membranes
- III. Transport Across Cell Membrane
Chapter 8: Overview of Metabolism and Cell Bioenergetics
- I. Overview of Metabolism
- II. Bioenergetics: Principles
Chapter 9: Metabolism of Carbohydrates I: Mainline Metabolic Pathways
- I. Transport of Glucose Into Cells
- II. Glycolysis
- III. Feeder Pathways
- IV. Tricarboxylic Acid Cycle
- V. Gluconeogenesis
- VI. Glycogen Metabolism
Chapter 10: Metabolism of Carbohydrates II: Secondary Pathways and Regulation of Blood Glucose Level
- I. Pentose Phosphate Pathway
- II. Uronic Acid Pathway
- III. Metabolism of Other Sugars
- IV. Sorbitol Pathway
- V. Regulation of Blood Glucose Level
Chapter 11: Lipid Metabolism I: Metabolism of Fatty Acids and Compound Lipids
- I. β-Oxidation
- II. Other Oxidative Pathways
- III. Ketone Body Production and Metabolism
- IV. De Novo Synthesis of Fatty Acids
- V. Chain Elongation and Desaturase Systems
- VI. Metabolism of Triacylglycerol
- VII. Adipose Tissue Metabolism
- VIII. Metabolism of Complex Lipids
Chapter 12: Lipid Metabolism II: Lipoproteins
- I. Lipoproteins
- II. Fatty Liver Syndrome
- III. Metabolism of Cholesterol
- IV. Atherosclerosis
- V. Prostaglandins
Chapter 13: Amino Acid and Protein Metabolism
- I. Nitrogen Metabolism
- II. Catabolism of Amino Group Nitrogen
- III. Catabolism of Carbon Skeleton of Amino Acids
- IV. Disorders of Amino Acid Metabolism
- V. Biosynthesis of Amino Acids
- VI. Amino Acids as Precursors of Specialized Products
- Exercises
Chapter 14: Electron Transport
- I. Electron Transport Chain (ETC)
- II. Oxidative Phosphorylation
- III. Mitochondrial Membrane Transporters
- IV. Enzymes Participating in Biological Oxidation
- V. Mitochondrial Myopathies
Chapter 15: Integration of Metabolism
- I. Hormonal Regulation of Major Metabolic Pathways
- II. Metabolic Interconnections and Organ Specialization
- III. Metabolic Adaptations in Three Fasting–Starvation States
- IV. Diabetes Mellitus
- V. Metabolism of Xenobiotics
- VI. Alcohol Metabolism
Chapter 16: Porphyrins and Bile Pigments
- I. General Characteristics of Porphyrins
- II. Biological Significance of Porphyrins
- III. Nomenclature
- IV. Synthesis of Haem
- V. Disorders of Porphyrin Metabolism: Porphyrias
- VI. Haem Breakdown
- VII. Jaundice
Chapter 17: Oxygen Transporters: Haemoglobin and Myoglobin
- I. Haemoglobin
- II. Haemoglobin Derivatives
- III. Haemoglobinopathies
- IV. Myoglobin
- V. Anaemias
Chapter 18: Vitamins
- I. Classification and Nomenclature
- II. Sources, Daily Requirements, and Deficiency of Vitamins
- III. Water-Soluble Vitamins
- IV. Fat-Soluble Vitamins
Chapter 19: Minerals
- I. Absorption, Transport, and Excretion of Minerals
- II. Mineral Deficiency or Excess
- III. Sources and Daily Requirements of Minerals
- IV. Major Elements
- V. Trace Elements
Chapter 20: Nucleic Acid Chemistry and Nucleotide Metabolism
- I. Nucleotides: Chemistry and Biological Significance
- II. Purine Metabolism
- III. Pyrimidine Metabolism
Chapter 21: Molecular Biology I: DNA Structure
- I. Structure of Deoxyribonucleic Acid (DNA)
- II. Some Physical Properties of DNA
- III. DNA as Genetic Material
- IV. Architecture of the Human Genome
- V. Some Commonly Used Terms Related to Molecular Genetics
- VI. Replication
- VII. Mutations
- VIII. Repair Systems for Mutated DNA
- IX. Defective DNA Repair and Human Diseases
- X. Site-Specific Recombination
Chapter 22: Molecular Biology II: Transcription and Translation
- I. Types of RNAs
- II. Transcription
- III. Genetic Code
- IV. Translation
- V. Protein Targeting
Chapter 23: Molecular Biology III: Regulation of Prokaryotic Gene Expression and Molecular Genetics
- I. Constitutive and Inducible Proteins
- II. Operon: A Coordinated Unit of Gene Expression
- III. Protein-DNA Interaction in Transcriptional Regulation
- IV. Regulatory Mechanism in Viruses
- V. Genetic Diseases
Chapter 24: Molecular Biology IV: Eukaryotic Chromosome and Gene Expression
- I. Replication has Multiple Sites of Origin
- II. Untranscribed Human DNA
- III. Gene Distribution Along DNA
- IV. Transcription
- V. Translation
- VI. Regulation of Eukaryotic Gene Expression
Chapter 25: Recombinant DNA Technology and Genetic Engineering
- I. Techniques and Enzymes Used in Manipulation of DNA
- II. DNA Amplification and Cloning
- III. DNA Library
- IV. Nucleotide Probes
- V. Blotting Techniques
- VI. Applications of Recombinant DNA Technology
- VII. Restriction Fragment Length Polymorphism
- VIII. Polymerase Chain Reaction (PCR)
- IX. Human Genome Project: Current Status and Future Goals
Chapter 26: Gastrointestinal Pathobiochemistry
- I. Digestion and Absorption
- II. Organ Function Tests
- III. Liver Function Tests
Chapter 27: Free Radicals in Health and Disease
- I. Incomplete Reduction of Oxygen
- II. Generation of Oxygen Free Radicals
- III. Damage Produced by Free Radicals
- IV. Free Radical Scavenger Systems
- V. Free Radicals in Aetiology of Disease
Chapter 28: Energy Metabolism and Nutrition
- I. Calorific Values
- II. Components of Energy Requirements
- III. Recommendations for Dietary Nutrients
- IV. Proximate Principles of Food
- V. Nutritional Importance of Carbohydrates
- VI. Nutritional Importance of Fats
- VII. Nutritional Importance of Proteins
- VIII. Balanced Diet
- IX. Nutritional Implications of Diseases
Chapter 29: Biochemical Endocrinology
- I. General Characteristics of Hormone Systems
- II. Hormone Receptors
- III. Mechanism of Action of Hormones
- IV. Neurotransmitters
- Exercises
Chapter 30: Action of Hormones
- I. Hypothalamus-Pituitary System
- II. Hypothalamic Hormones
- III. Anterior Pituitary Hormones
- IV. Hormones of Posterior Pituitary
- V. Hormones of Thyroid Gland
- VI. Hormones of Adrenal Cortex
- VII. Hormones of Adrenal Medulla
- VIII. Gastrointestinal Hormones
- IX. Hormones of Gonads
- X. Androgens
- XI. Oestrogens
- XII. Progesterone
Chapter 31: Calcium and Phosphate: Metabolism and Regulation
- I. Calcium
- II. Phosphorus
Chapter 32: Cancer
- I. Tumours: Benign and Malignant
- II. Distinctive Features of Malignant Cells
- III. Aetiology
- IV. Molecular Basis of Protooncogene Activation
- V. Some Oncoproteins and Associated Cancers
- VI. Tumour Markers
Chapter 33: Immunology
- I. Historical Milestones
- II. Non-Specific and Specific Immune Responses
- III. Antigens and Immunogens
- IV. Role of Lymphocytes
- V. Organs of the Immune System
- VI. Cells of the Immune System
- VII. Molecules of Immune Response
- VIII. Immunoglobulins
- IX. More about Complement Cascade
- X. The Recognition of and Response to Nonself
- XI. Cellular Cooperation in the Immune Response
- XII. Non-Specific Effector Cells are Influenced by TH Cells and Immunoglobulins
- XIII. Specific Immune Response to Some Infections
- IX More about Complement Cascade
- X The Recognition of and Response to Nonself
- XI Cellular Cooperation in the Immune Response
- XII Non-specific Effector Cells are influenced by TH Cells and Immunoglobulins
- XIII Specific Immune Response to Some Infections
- XIV Vaccines
- XV Immunological Techniques
- XVI Immunologic Dysfunction
- Chapter 34: Tests for thyroid
- I Thyroid Function Tests
- II Adrenal Function Tests
- III Renal Func
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