Biomedical polymers and polymer therapeutics 1st Edition by Emo Chiellini, Junzo Sunamoto, Claudio Migliaresi, Raphael Ottenbrite, Daniel Cohn 0306464721 978-0306464720

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ISBN 10: 0306464721

ISBN 13: 978-0306464720

Author: Emo Chiellini; Junzo Sunamoto; Claudio Migliaresi, Raphael M. Ottenbrite, Daniel Cohn

Proceedings of the Third International Symposium on Frontiers in Biomedical Polymers including Polymer Therapeutics: From Laboratory to Clinical Practice, held May 23-27, 1999, in Shiga, Japan.
This book focuses on the progress and unique discoveries in the interdisciplinary scientific and technological area of biomedical application of polymers. The topics include polymeric materials for biomedical and pharmaceutical applications, as well as polymeric materials in therapeutics.

Biomedical polymers and polymer therapeutics 1st Table of contents:

Part 1 Biomedical Polymers and Polymer Therapeutics

Molecular Design of Biodegradable Dextran Hydrogels for the Controlled Release of Proteins

1. INTRODUCTION

2. PROTEIN RELEASE FROM NON-DEGRADING DEXTRAN HYDROGELS

3. PROTEIN RELEASE FROM ENZYMATICALLY DEGRADING DEXTRAN HYDROGELS

4. PROTEIN RELEASE FROM CHEMICALLY DEGRADING DEXTRAN HYDROGELS

5. PROTEIN RELEASE FROM DEGRADING DEXTRAN MICROSPHERES

6. IN VIVO BIOCOMPATIBILITY OF DEXTRAN BASED HYDROGELS

7. CONCLUSION

ACKNOWLEDGMENTS

REFERENCES

Biodegradable Nanospheres: Therapeutic Applications

1. INTRODUCTION

2. FORMULATION OF NANOSPHERES

3. ORAL DELIVERY

4. TARGETED DELIVERY

5. GENE DELIVERY

6. VACCINE DELIVERY

7. CANCER CHEMOTHERAPY

8. INTRAMUSCULAR DELIVERY

9. LOCALISED DRUG DELIVERY

10. CONCLUSION

ACKNOWLEDGMENTS

REFERENCES

Application to Cancer Chemotherapy of Supramolecular System

1. INTRODUCTION

2. METHODS AND RESULTS

3. CONCLUSION

ACKNOWLEDGMENTS

REFERENCES

DDS in Cancer Chemotherapy

1. INTRODUCTION

2. CLINICAL STUDY OF ADRIAMYCIN ENCAPSULATED PEG-IMMUNOLIPOSOME

3. DEVELOPMENT OF MICELLES INCORPORATED KRN5500

4. CONCLUSION

REFERENCES

Cellulose Capsules-An Alternative to Gelatin

1. INTRODUCTION

2. CHARACTERISTICS OF HPMC FILM

3. CHARACTERISTICS OF HPMC CAPSULES

4. LIQUID OR SEMI-SOLID FILLING

5. DISINTEGRATION AND DISSOLUTION

6. IN VIVO EVALUATION

7. CONCLUSION

ACKNOWLEDGMENTS

REFERENCES

Polymeric Hydrogels in Drug Release

1. INTRODUCTION

2. PREPARATION OF HYDROGELS

3. EVALUATION OF THE INTERACTIONS OF HEMA HYDROGELS WITH WATER

4. METHRONIDASOLE LOADED HEMA HYDROGELS

5. MODIFIED HEMA HYDROGELS FOR TISSUE ENGINEERING APPLICATIONS

6. CONCLUSIONS

ACKNOWLEDGMENTS

REFERENCES

Biodegradable Polyrotaxanes Aiming at Biomedical and Pharmaceutical Applications

1. INTRODUCTION

2. BIODEGRADABLE POLYROTAXANES FOR DRUG DELIVERY SYSTEMS

3. BIODEGRADABLE POLYROTAXANES FOR TISSUE ENGINEERING

4. POLYROTAXANES FOR STIMULI-RESPONSIVE MATERIALS

5. CONCLUSION

ACKNOWLEDGMENTS

REFERENCES

Liposomes Linked With Time-Release Surface Peg

1. INTRODUCTION

2. MATERIALS AND METHODS

3. RESULTS AND DISCUSSION

4. CONCLUSION

ACKNOWLEDGMENTS

REFERENCES

Carrier Design: Influence of Charge on Interaction of Branched Polymeric Polypeptides with Phospholipid Model Membranes

1. INTRODUCTION

2. SYNTHESIS AND CHEMICAL STRUCTURE

3. REVERSED PHASE HPLC CHARACTERISATION

4. SURFACE ACTIVITY OF POLYMERS

5. PENETRATION OF POLYMERS IN MONOLAYERS

6. INTERACTION OF POLYMERS WITH PHOSPHOLIPID BILAYERS

7. CONCLUSION

ACKNOWLEDGMENTS

REFERENCES

Block Copolymer-Based Formulations of Doxorubicin Effective Against Drug Resistant Tumours

1. INTRODUCTION

2. SP1049 FORMULATION AND ITS IN VITRO PROPERTIES

3. EFFICACY COMPARISON OF DOXORUBICIN AND SP1049C ON THE IN VIVO TUMOUR MODELS

4. COMPARISON OF PLASMA PHARMACOKINETICS AND BIODISTRIBUTION OF SP1049C AND DOXORUBICIN IN NORMAL AND TUMOUR-BEARING MICE

5. TOXICITY OF SP1049C

6. CONCLUSION

ACKNOWLEDGMENTS

REFERENCES

Preparation of Poly(lactic Acid)-Grafted Polysaccharides as Biodegradable Amphiphilic Materials

I. INTRODUCTION

2. EXPERIMENTAL

3. RESULTS AND DISCUSSION

4. CONCLUSION

ACKNOWLEDGMENTS

REFERENCES

Phospholipid Polymers for Regulation of Bioreactions on Medical Devices

1. INTRODUCTION

2. MOLECULAR DESIGN OF THE MPC POLYMERS

3. MECHANISM OF THE PROTEIN ADSORPTION RESISTANCE BY THE MPC POLYMERS

4. APPLICATIONS OF THE MPC POLYMERS

5. CONCLUSION

ACKNOWLEDGMENTS

REFERENCES

Relative Polycation Interactions with Whole Bloos and Model Media

1. INTRODUCTION

2. EXPERIMENTAL

3. RESULTS

4. DISCUSSION

5. CONCLUSIONS

ACKNOWLEDGMENTS

REFERENCES

Influence of Plasma Protein and Platelet Adhesion on Covalently Coated Biomaterials with Major Sequences of Twenty Regioselective Modified N-oro-Desulphated Heparin/Heparan Derivatives

1. INTRODUCTION

3. RESULTS

4. DISCUSSION

ACKNOWLEDGMENTS

REFERENCES

Preparation and Surface Analysis of Haemocompatible Nanocoatings with Amino- and Carboxyl Group Containing Polysaccharides

1. INTRODUCTION

2. MATERIALS AND METHODS

3. RESULTS

4. DISCUSSION

5. CONCLUSION

ACKNOWLEDGMENTS

REFERENCES

Isolation and Characterisation of Endothelial Cell Surface Heparan Sulphate from Whole Bovine Lung for Coating of Biomaterials to Improve Haemocompatibility

1. INTRODUCTION

2. MATERIALS AND METHODS

3. RESULTS

4. CONCLUSION

ACKNOWLEDGMENTS

REFERENCES

Composite Materials as Scaffolds for Tissue Engineering

1. INTRODUCTION

2. EXPERIMENTAL

3. RESULTS AND DISCUSSION

4. CONCLUSION

REFERENCES

Protein Immobilization onto Newly Developed Polyurethane-Maleamides for Endothelial Cell Growth

1. INTRODUCTION

2. MATERIALS AND METHODS

3. RESULTS AND DISCUSSION

4. CONCLUSION

ACKNOWLEDGMENTS

REFERENCES

Functionalized Polymers of Malic Acid Stimulate Tissue Repair Presumably by Regulating Heparin Growth Factors Bioavailability

I. INTRODUCTION

2. SYNTHESIS OF TERPOLYMER

3. BIOLOGICAL EVALUATION ON BONE REPAIR

4. BIOLOGICAL EVALUATION ON MUSCLE REGENERATION

5. STUDY OF TOXICITY OF TERPOLYMER

6. CONCLUSION

ACKNOWLEDGMENTS

REFERENCES

Temperature-Control of Interactions of Thermosensitive Polymer Modified Liposomes with Model Membranes and Cells

1. INTRODUCTION

2. POLYMER SYNTHESIS

3. PREPARATION OF POLYMER-MODIFIED LIPOSOMES

4. INTERACTION OF THERMOSENSITIVE POLYMER-MODIFIED CATIONIC LIPOSOMES WITH MODEL MEMBRANES

4.1 Zeta Potential

4.2 Association of Cationic Liposomes with Anionic Liposomes

4.3 Fusion of Cationic Liposomes with Anionic Liposomes

5. INTERACTION OF THERMOSENSITIVE POLYMER-MODIFIED EYPC LIPOSOMES WITH CV1 CELLS

5.2 Liposome-Mediated Delivery of MTX to CV1 Cells

6. CONCLUSION

REFERENCES

Part 2 Polymers in Diagnosis and Vaccination

The Use of Polychelating and Amphiphilic Polymers in Gamma, MR and CT Imaging

1. INTRODUCTION

2. POLYCHELATING POLYMER-BASED IMMUNOCONJUGATES FOR TARGETED DIAGNOSTIC IMAGING

3. POLYCHELATING AMPHIPHILIC POLYMERS (PAP) AS KEY COMPONENTS OF MICROPARTICULATE DIAGNOSTIC AGENTS

4. CT-VISUALIZATION OF BLOOD POOL WITH LONG-CIRCULATING IODINE-CONTAINING MICELLES

REFERENCES

Conjugation Chemistries to Reduce Renal Radioactivity Levels of Antibody Fragments

1. INTRODUCTION

2. RENAL HANDLING OF ANTIBODY FRAGMENTS

3. METABOLIZABLE LINKAGES TO FACILITATE EXCRETION OF RADIOMETABOLITES FROM RENAL LYSOSOMES

4. METABOLIZABLE LINKAGES TO LIBERATE RADIOMETABOLITES FROM ANTIBODY FRAGMENTS BY RENAL BRUSH BORDER ENZYMES

5. CONCLUSION

REFERENCES

Synthetic Peptide and Their Polymers as Vaccines

1. INTRODUCTION

2. CONCLUSION

ACKNOWLEDGMENTS

REFERENCES

Development of Fusogenic Liposomes and Its Application for Vanccine

1. INTRODUCTION

2. FL CAN DELIVER MATERIALS INTO CYTOPLASM

3. FL AS A GENE TRANSFER VECTOR

4. FL AS A VACCINE CARRIER

ACKNOWLEDGMENTS

REFERENCES

A Novel Hydrophobized Polysaccharide/Oncoprotein Complex Vaccine for Her2 Gene Expressing Cancer

1. INTRODUCTION

2. RESULTS AND DISCUSSION

3. CONCLUSION

REFERENCES

Part 3 Polymers in Gene Therapy

Pharmaceutical Aspects of Gene Therapy

1. INTRODUCTION

2. POTENTIAL DISEASE TARGETS FOR GENE THERAPY

3. CLINICAL TRIALS OF GENE THERAPY

4. VIRAL GENE DELIVERY SYSTEMS

5. NON-VIRAL GENE DELIVERY SYSTEMS

6. POLYMER-BASED NON-VIRAL GENE DELIVERY SYSTEMS

REFERENCES

High-Molecular Weight Polyethylene Glycols Conjugated to Antisense Oligonucleotides

1. INTRODUCTION

2. POLYMER-CONJUGATED OLIGONUCLEOTIDES

3. LIQUID-PHASE SYNTHESIS OF PEG-CONJUGATED OLIGONUCLEOTIDES

4. CONCLUSION

ACKNOWLEDGMENTS

REFERENCES

Photodynamic Antisense Regulation of Human Cervical Carcinoma Cell

1. INTRODUCTION

2. EXPERIMENTAL

3. RESULTS AND DISCUSSION

ACKNOWLEDGMENTS

REFERENCES

In Vitro Gene Delivery by Using Supramolecular Systems

1. INTRODUCTION

2. THE DNA/PEG-LIPID COMPLEX

3. THE DNA/GLYCOLIPID COMPLEX

4. THE DNA/CHITOSAN COMPLEX

5. CONCLUSION

ACKNOWLEDGMENTS

REFERENCES

Ribozyme Technology 1: Hammerhead Ribozymes as Tools for the Suppression of Gene Expression

1. INTRODUCTION

2. PARTICIPATION OF THE TRANSCRIPTIONAL CO-ACTIVATOR CBP IN SEVERAL SIGNALING PATHWAYS

3. CONSTRUCTION OF tRNAVAL-RIBOZYME EXPRESSION OF THE GENE FOR CBP

4. A ROLE FOR THE TRANSCRIPTIONAL CO-ACTIVATOR CBP DURING THE RA-INDUCED DIFFERENTIATION OF F9 CELLS

5. CONCLUSION

REFERENCES

Ribozyme Technology 2: Novel Allosterically Controllable Ribozymes, the Maxizymes, with Considerable Potential as Geneinactivating Agents

1. INTRODUCTION

2. DISCOVERY OF MAXIZYMES THAT ACT AS A DIMERIC FORM OF SHORT RIBOZYMES

3. DETECTION OF THE FORMATION OF MAXIZYME DIMERS BY HIGH-RESOLUTION NMR SPECTROSCOPY

4. CONSTRUCTION OF tRNAVAL-EMBEDDED MAXIZYMES AND DETECTION OF THE FORMATION OF DIMERIC STRUCTURES BY tRNAVAL-EMBEDDEDM AXIZYMES

5. THE INTRACELLULAR ACTIVITIES OF tRNAVAL-DIMERIC MAXIZYMES; SIMULTANEOUS CLEAVAGE OF HIV-1 TAT mRNA AT TWO INDEPENDENT SITES BY HETERODIMERIC MAXIZYMES

6. CHRONIC MYELOGENOUS LEUKEMIA (CML) AND THE POTENTIAL FOR RIBOZYME THERAPY

7. SPECIFIC DESIGN OF AN ALLOSTERICALLY CONTROLLABLE MAXIZYME

8. SPECIFICITY OF THE CLEAVAGE OF THE CHIMERIC BCR-ABL SUBSTRATE IN VITRO

9. THE ACTIVITY AND SPECIFICITY OF THE MAXIZYME AGAINST AN ENDOGENOUS BCR-ABL CELLULAR TARGET

10. DIRECT EVIDENCE FOR THE ENHANCED ACTIVATION OF CASPASE-3 BY THE MAXIZYME

11. CONCLUSION

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