Illustrated Pathology of the Bone Marrow 1st Edition by Attilio Orazi, Dennis OMalley, Daniel Arber ISBN 9780511222764 0511222769
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Authors:Attilio Orazi; Dennis P. O’Malley; Daniel A. Arber , Series:Pathology [8] , Tags:Medical; Pathology; Hematology; Oncology; General , Author sort:Orazi, Attilio & O’Malley, Dennis P. & Arber, Daniel A. , Ids:Google; 9781139455527 , Languages:Languages:eng , Published:Published:Jul 2006 , Publisher:CAMBRIDGE UNIVERSITY PRESS , Comments:Comments:This book provides a highly illustrated and comprehensive account of the diseases of the human bone marrow. It will help experienced clinicians and those in training to answer the practical diagnostic questions that arise during the routine analysis of bone marrow core biopsy specimens. Throughout the text, histologic interpretation is integrated with clinical and laboratory findings. Emphasis is placed on the evaluation of peripheral blood, aspirate smear, clot section and core biopsy, as well as ancillary techniques including flow cytometry and immunohistochemistry in the diagnosis of hematologic disorders of the marrow. The text is illustrated with numerous color figures, charts and tables, and descriptions of real case situations using the most up-to-date classification systems. Illustrated Pathology of Bone Marrow should be read by all pathologists, hematologists and laboratory technicians involved in the analysis of bone marrow specimens.
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ISBN 10: 0511222769
ISBN 13: 9780511222764
Author: Attilio Orazi, Dennis OMalley, Daniel Arber
Illustrated Pathology of the Bone Marrow 1st Edition Table of contents:
1 Introduction
Indications for bone marrow examination
Obtaining the bone marrow biopsy
REFERENCES
2 The normal bone marrow and an approach to bone marrow evaluation of neoplastic and proliferative p
Introduction
Evaluation of stainable iron
Marrow aspirate smears
Bone marrow biopsy
Evaluation of bone marrow extracellular stroma, marrow fibrosis, and mesenchymal cells
Evaluation of fibrosis
Ancillary techniques useful in bone marrow evaluation
Cytochemistry
Immunophenotyping
Flow cytometry
Immunohistochemistry
Molecular genetic and cytogenetic analysis
The bone marrow report
REFERENCES
3 Granulomatous and histiocytic disorders
Granulomas in bone marrow
Hemophagocytic syndromes
Storage diseases
Non-leukemic histiocytic disorders
REFERENCES
4 The aplasias
Introduction
Aplastic anemia
Constitutional aplastic anemia
Fanconi anemia and Eastern?Dameshek anemia
Paroxysmal nocturnal hemoglobinuria
Redcell aplasia
Congenital red cell aplasia
Acquired red cell aplasia
Parvovirus-related erythroblastopenia
Transient erythroblastopenia of childhood
Other causes of acquired pure red cell aplasia
Granulocyte aplasia
Congenital granulocyte aplasia
Acquired granulocyte aplasia
Megakaryocyte aplasia
REFERENCES
5 The hyperplasias
Introduction
Erythroid hyperplasias
Erythroid hyperplasias associated with normocytic anemia
Erythroid hyperplasia associated with macrocytic anemia
Congenital dyserythropoietic anemias
Erythroid hyperplasia associated with microcytic anemia
Other causes of erythroid hyperplasia
Granulocytic, monocytic, and lymphocytic hyperplasias
Neutrophilia
Monocytosis
Eosinophilia
Basophilia and mast cell hyperplasia
Lymphocytosis
Megakaryocytic hyperplasias
Hyperplasias related to growth factors
REFERENCES
6 Other non-neoplastic marrow changes
Fibrosis
Necrosis
Serous fat atrophy
Abnormalities of bone trabeculae
REFERENCES
7 Myelodysplastic syndromes
Introduction
Peripheral blood
Bone marrow aspirate
Bone marrow biopsy
A poptosis by in situ end labeling
Flow cytometry
Apoptosis evaluation by flow cytometry in MDS
Cytogenetic analysis
Subtypes of myelodysplastic syndromes
Refractory anemia and refractory anemia with ringed sideroblasts
Refractory cytopenia with multilineage dysplasia
Refractory anemia with excess of blasts
Refractory anemia with excess of blasts in transformation
5q syndrome
Myelodysplastic syndromes with 17p abnormalities
Myelodysplastic syndromes with fibrosis
Therapy-related myelodysplastic syndrome
Hypoplastic myelodysplastic syndrome
Myelodysplastic syndrome with eosinophilia
Pediatric myelodysplastic syndromes and myelodysplastic/myeloproliferative conditions and their diff
REFERENCES
8 Acute leukemia
Introduction
Acute lymphoblastic leukemia
Acute myeloid leukemia
Acute myeloid leukemias with recurrent genetic abnormalities
Acute myeloid leukemia with multilineage dysplasia and therapy-related acute myeloid leukemia
Acute myeloid leukemia not otherwise categorized
Biphenotypic acute leukemia
Acute undifferentiated leukemia
REFERENCES
9 Chronic myeloproliferative disorders and systemic mastocytosis
Introduction
Chronic myelogenous leukemia
Chronic neutrophilic leukemia
Chronic eosinophilic leukemia/hypereosinophilic syndrome
Chronic basophilic leukemia
Chronic idiopathic myelofibrosis with myeloid metaplasia
Polycythemia vera
Essential thrombocythemia
Systemic mastocytosis
REFERENCES
10 Myelodysplastic/myeloproliferative disorders
Introduction
Atypical chronic myeloid leukemia
Chronic myelomonocytic leukemia
Juvenile myelomonocytic leukemia
Other myelodysplastic/myeloproliferative syndromes
REFERENCES
11 Chronic lymphoproliferative disorders and malignant lymphoma
Introduction
Small B-cell proliferations
Chronic lymphocytic leukemia/small lymphocytic lymphoma
B-cell prolymphocytic leukemia
Atypical CLL and mixed CLL/PLL
Lymphoplasmacytic lymphoma
Hairy cell leukemia
Marginal zone lymphomas
Follicular lymphoma
Mantle cell lymphoma
Aggressive B-cell lymphomas
Diffuse large B-cell lymphoma
T-cell/histiocyte-rich large B-cell lymphoma
Intravascular large B-cell lymphoma
Burkitt and Burkitt-like lymphoma
Lymphoblastic leukemia/lymphoma
T and NK/T-cell lymphoma
T-cell prolymphocytic leukemia
T-cell large granular lymphocytic leukemia and aggressive NK-cell leukemia
Adult T-cell leukemia/lymphoma
Mycosis fungoides/S?zary syndrome
Other peripheral T-cell lymphomas
Hodgkin lymphoma
Lymphoid aggregates
REFERENCES
12 Immunosecretory disorders/plasma cell disorders and lymphoplasmacytic lymphoma
Introduction
Benign plasma cells and reactive plasmacytosis
Monoclonal gammopathy of undetermined significance
Plasma cell myeloma
Peripheral blood
Bone marrow
Plasma cell myeloma variants
Indolent/smoldering myeloma
Non-secretory
Plasma cell leukemia
Anaplastic myeloma
Immunohistochemistry in plasma cell disorders
Cytogenetics in plasma cell disorders
Solitary plasmacytoma of bone and extraosseous plasmacytoma
POEMS syndrome/osteosclerotic myeloma
Amyloidosis
Monoclonal light and heavy chain deposition diseases
Lymphoplasmacytic lymphoma
Bone marrow
Ancillary studies
REFERENCES
13 Metastatic lesions
Introduction
Peripheral blood and bone marrow aspirate
Bone marrow biopsy
Metastatic tumors in adults
Metastatic tumors in children
REFERENCES
14 Post-therapy bone marrow changes
Introduction
General marrow changes after myeloablative therapy
Disease-specific changes after therapy
Acute leukemia
Acute promyelocytic leukemia
Chronic myelogenous leukemia
Growth factor changes
Granulomas
Necrosis
Fibrosis
REFERENCES
Index
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