A Textbook of Modern Toxicology 3rd Edition by Ernest Hodgson ISBN 047126508X 9780471265085

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Product details:
ISBN 10: 047126508X
ISBN 13: 9780471265085
Author: Ernest Hodgson

A Textbook of Modern Toxicology 3rd Edition Table of contents:

1. Introduction to Toxicology

• Definition and Scope of Toxicology
• Historical Overview of Toxicology
• Toxicology and Other Disciplines: Chemistry, Biology, and Medicine
• The Role of Toxicologists

2. Mechanisms of Toxicity

• Toxicodynamics: How Chemicals Cause Harm
• Receptor Theory and Signal Transduction
• Dose-Response Relationships
• Factors Modifying Toxic Effects: Genetics, Gender, and Age

3. Absorption, Distribution, Metabolism, and Excretion

• Routes of Exposure: Inhalation, Ingestion, Dermal
• Absorption and Bioavailability
• The Role of the Liver in Biotransformation
• Elimination and Half-life of Toxicants

4. Toxicokinetics

• Models of Toxicokinetics
• Dose, Time, and Concentration Relationships
• Metabolic Pathways and Enzyme Systems
• Physiologically-Based Pharmacokinetic Models

5. Toxicology of the Nervous System

• Neurotoxicity and Mechanisms of Injury
• Effects of Toxicants on the Peripheral and Central Nervous Systems
• Neurotransmitters and Neurotoxicants
• Examples of Neurotoxic Substances

6. Toxicology of the Liver and Kidneys

• Hepatotoxicity: Mechanisms and Biomarkers
• Nephrotoxicity: Kidney Damage and Repair
• Chemical-induced Organ Injury: Liver and Kidney
• Specific Toxicants Affecting These Organs

7. Toxicology of the Cardiovascular System

• Cardiovascular Toxicity: Mechanisms and Outcomes
• Effects on Heart Function and Blood Pressure
• Toxicants Inducing Arrhythmias and Heart Failure
• Examples of Cardiovascular Toxicants

8. Toxicology of the Respiratory System

• Pulmonary Toxicology and Mechanisms of Injury
• Effects of Toxicants on the Airways and Lungs
• Occupational and Environmental Lung Toxicants
• Acute and Chronic Respiratory Toxicity

9. Toxicology of the Skin

• Dermal Toxicology: Absorption and Effects
• Irritants and Sensitizers: Mechanisms of Action
• Chemical Burns, Rashes, and Allergies
• Occupational and Environmental Skin Toxicants

10. Toxicology of the Reproductive System

• Endocrine Disruptors and Reproductive Toxicity
• Male and Female Reproductive Toxicology
• Teratogenicity and Developmental Toxicology
• Chemical Effects on Fertility and Pregnancy

11. Toxicology of the Immune System

• Immunotoxicology: Effects of Chemicals on the Immune System
• Autoimmunity and Hypersensitivity Reactions
• Immunosuppression and Increased Susceptibility to Infections
• Chemical-induced Immune System Disorders

12. Environmental and Industrial Toxicology

• Environmental Pollutants and Their Toxic Effects
• Industrial Toxicology: Occupational Hazards
• Air, Water, and Soil Contaminants
• Risk Assessment and Environmental Toxicology

13. Toxicology of Drugs and Pharmaceuticals

• Pharmacotoxicology: The Toxicology of Pharmaceuticals
• Drug Interactions and Toxicity
• Adverse Drug Reactions and Mechanisms
• Regulatory and Safety Guidelines for Drug Development

14. Toxicology of Food and Consumer Products

• Additives, Contaminants, and Toxins in Food
• Pesticides and Herbicides
• Consumer Products: Cosmetics, Household Products, and Packaging
• Risk Assessment and Food Safety

15. Methods in Toxicology

• In Vitro and In Vivo Testing Methods
• Toxicological Screening and High-Throughput Testing
• Biomarkers and Genotoxicity Testing
• Advanced Toxicology Testing and Data Interpretation

16. Risk Assessment and Toxicology

• Principles of Toxicological Risk Assessment
• Hazard Identification, Dose-Response, and Exposure Assessment
• Risk Characterization and Regulatory Toxicology
• Risk Communication and Public Health

17. Toxicology of Cancer

• Carcinogenesis: Mechanisms and Pathways
• Chemical Carcinogens and Their Modes of Action
• Epidemiology of Cancer and Environmental Exposures
• Risk Assessment for Cancer

18. Toxicology of Aging

• Aging and Susceptibility to Toxicants
• Age-related Changes in Toxicokinetics and Toxicodynamics
• Long-term Exposure to Toxicants and Chronic Diseases
• Aging Populations and Environmental Toxicology

19. Emerging Issues in Toxicology

• Nanotoxicology and the Risks of Nanomaterials
• Endocrine Disruption and Hormone Mimics
• The Toxicology of Climate Change and Emerging Contaminants
• Future Directions in Toxicological Research

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