Genomic Imprinting methods and protocols Volume 181 1st Edition by Andrew Ward ISBN 089603741X 9780896037410
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Authors:Andrew Ward , Series:Pathology [14] , Tags:Pathology; Biochemical Systems , Author sort:Ward, Andrew , Languages:Languages:eng , Published:Published:Jun 2002 , Publisher:Humana Press , Comments:Genomic imprinting is the process by which gene activity is regulated according to parent of origin.Usually, this means that either the maternally inherited or the paternally inherited allele of a gene is expressed while the opposite allele is repressed. The phenomenon is largely restricted to mammals and flowering plants and was first recognized at the level of whole genomes. Nuclear transplantation experiments carried out in mice in the late 1970s established the non-equivalence of the maternal and paternal genomes in mammals, and a similar conclusion was drawn from studies of interploidy crosses of flowering plants that extend back to at least the 1930s. Further mouse genetic studies, involving animals carrying balanced translocations (reviewed in Chapter 3), indicated that imprinted genes were likely to be widely scattered and would form a minority within the mammalian genome. The first imprinted genes were identified in the early 1990s; over forty are now known in mammals and the list continues steadily to expand
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ISBN 10: 089603741X
ISBN 13: 9780896037410
Author: Andrew Ward
Genomic Imprinting methods and protocols Volume 181 1st Edition Table of contents:
Chapter 1: Introduction to Genomic Imprinting
- Overview of Genomic Imprinting
- Mechanisms of Imprinting: DNA Methylation, Histone Modification, and Chromatin Structure
- The Role of Imprinting in Development and Disease
- Examples of Imprinted Genes and Disorders
- Evolutionary Aspects of Genomic Imprinting
Chapter 2: Methods for Studying Imprinted Genes
- Identifying Imprinted Genes in Mammals
- Genetic Approaches: Knockout Models and Mutagenesis
- Experimental Models for Studying Imprinting
- Genomic Imprinting in Humans and Mice: Comparative Studies
- Use of High-Throughput Sequencing for Identifying Imprinting Regions
Chapter 3: DNA Methylation and Imprinting
- The Role of DNA Methylation in Genomic Imprinting
- Techniques for Analyzing DNA Methylation Patterns
- Methylation-Specific PCR (MSP)
- Bisulfite Sequencing and Methylation Analysis
- DNA Methylation Profiling with Microarrays
- The Impact of Epigenetic Modifications on Imprinting
Chapter 4: Chromatin and Histone Modifications in Imprinting
- Chromatin Structure and the Regulation of Imprinted Gene Expression
- Histone Modifications and Their Role in Imprinting
- Chromatin Immunoprecipitation (ChIP) for Studying Histone Modifications
- Epigenetic Regulation of Imprinting by Non-Coding RNAs
- Techniques for Chromatin Analysis and Imprinting Studies
Chapter 5: RNA-Based Approaches in Imprinting Research
- The Role of Long Non-Coding RNAs in Imprinting
- Imprinted Non-Coding RNAs and Their Regulatory Functions
- Techniques for Studying RNA Expression and Imprinting
- Quantitative RT-PCR for Imprinted Gene Expression
- RNA Sequencing and Its Use in Imprinting Studies
- Investigating Imprinted Gene Expression via RNA Interference
Chapter 6: Mouse Models for Genomic Imprinting
- The Use of Mice in Studying Genomic Imprinting
- Engineering Mouse Models to Investigate Imprinted Gene Function
- Knockout and Knock-in Models
- Transgenic Models for Studying Imprinting Disorders
- Techniques for Characterizing Imprinting Phenotypes in Mice
Chapter 7: Imprinting Disorders: Mechanisms and Diagnosis
- Genetic and Epigenetic Causes of Imprinting Disorders
- Prader-Willi Syndrome, Angelman Syndrome, and Other Disorders
- Diagnostic Methods for Imprinting Disorders
- Methylation Analysis for Diagnosing Imprinting Defects
- SNP Arrays and Next-Generation Sequencing for Imprinting Disorders
- Genetic Counseling and Therapeutic Approaches
Chapter 8: Imprinting in Plants and Non-Mammalian Systems
- Genomic Imprinting in Plants: Mechanisms and Examples
- Imprinting in Non-Mammalian Systems: Birds, Insects, and Amphibians
- Comparing Genomic Imprinting Across Species
- Experimental Techniques for Studying Imprinting in Non-Mammalian Systems
Chapter 9: Imprinting and Disease: Implications for Cancer
- The Role of Imprinting in Tumorigenesis
- Imprinting and Tumor Suppressor Genes
- Imprinting and Oncogenes: Insights from Cancer Models
- Techniques for Studying Imprinting in Cancer Cells
- Clinical Implications of Imprinting Disorders in Oncology
Chapter 10: Emerging Techniques in Imprinting Research
- Next-Generation Sequencing (NGS) and Its Impact on Imprinting Studies
- CRISPR/Cas9 and Gene Editing for Studying Imprinting
- Single-Cell Technologies in Imprinting Research
- Advances in Epigenetic Therapies Targeting Imprinting Disorders
- Future Directions in Genomic Imprinting Research
Chapter 11: Ethical and Legal Considerations in Imprinting Research
- Ethical Issues in Studying Genomic Imprinting
- Imprinting and Reproductive Technologies: Ethical Concerns
- Legal Implications of Imprinting Research in Human Genetics
- The Role of Genetic Counseling in Imprinting Disorders
Appendices
- Protocols for Laboratory Techniques in Imprinting Research
- DNA Extraction and Bisulfite Treatment Protocols
- ChIP-Seq Protocols for Imprinting Studies
- RNA Extraction and qRT-PCR Methods for Imprinted Gene Expression
- Mouse Model Generation for Imprinting Research
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