Medicinal Chemistry A Molecular and Biochemical Approach 3RD EDITION BY Thomas Nogrady, Donald F Weaver ISBN 9780195104561 0195104560

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ISBN 10: 0195104560
ISBN 13: 9780195104561 
Author: Thomas Nogrady, Donald F Weaver

Fully updated and rewritten by a basic scientist who is also a practicing physician, the third edition of this popular textbook remains comprehensive, authoritative and readable. Taking a receptor-based, target-centered approach, it presents the concepts central to the study of drug action in a logical, mechanistic way grounded on molecular and principles. Students of pharmacy, chemistry and pharmacology, as well as researchers interested in a better understanding of drug design, will find this book an invaluable resource. Starting with an overview of basic principles, Medicinal Chemistry examines the properties of drug molecules, the characteristics of drug receptors, and the nature of drug-receptor interactions. Then it systematically examines the various families of receptors involved in human disease and drug design. The first three classes of receptors are related to endogenous molecules: neurotransmitters, hormones and immunomodulators. Next, receptors associated with cellular organelles (mitochondria, cell nucleus), endogenous macromolecules (membrane proteins, cytoplasmic enzymes) and pathogens (viruses, bacteria) are examined. Through this evaluation of receptors, all the main types of human disease and all major categories of drugs are considered. There have been many changes in the third edition, including a new chapter on the immune system. Because of their increasingly prominent role in drug discovery, molecular modeling techniques, high throughput screening, neuropharmacology and genetics/genomics are given much more attention. The chapter on hormonal therapies has been thoroughly updated and re-organized. Emerging enzyme targets in drug design (e.g. kinases, caspases) are discussed, and recent information on voltage-gated and ligand-gated ion channels has been incorporated. The sections on antihypertensive, antiviral, antibacterial, anti-inflammatory, antiarrhythmic, and anticancer drugs, as well as treatments for hyperlipidemia and peptic ulcer, have been substantially expanded. One new feature will enhance the book’s appeal to all readers: clinical-molecular interface sections that facilitate understanding of the treatment of human disease at a molecular level.

Medicinal Chemistry A Molecular and Biochemical Approach 3RD EDITION Table of contents:

1. Basic Principles of Drug Design I—Drug Molecules: Structure and Properties

1.1 Definition and Properties of a Drug Molecule

1.2 Physicochemical Properties of Drug Molecules

1.3 Shape (Geometric, Conformational, Topological, and Steric) Properties of Drug Molecules

1.4 Stereochemical Properties of Drug Molecules

1.5 Electronic Properties of Drug Molecules

1.6 Predicting the Properties of Drug Molecules: Quantum Mechanics and Molecular Mechanics

Selected References

2. Basic Principles of Drug Design II—Receptors: Structure and Properties

2.1 The Receptor Concept and its History

2.2 The Nature of Receptors and Criteria for Receptor Identity

2.3 Definitions of Drug–Receptor Binding Interactions

2.4 Definitions of Classical Binding Terms for Drug–Receptor Interactions

2.5 Classical Theories of Drug–Receptor Binding Interactions

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