Conquering RAS From Biology to Cancer Therapy 1st edition by Asfar Azmi 9780128035412 0128035412

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ISBN 10: 0128035412
ISBN 13: 9780128035412 
Author: Asfar Azmi

Conquering RAS: From Biology to Cancer Therapy provides introductory knowledge on how modern RAS biology is taking shape in light of newer technological development. Each chapter is written in a manner that emphasizes simplicity and readability for both new investigators and established researchers. While RAS biology has been intensively studied for more than three decades, we are yet to see any effective therapeutics that could interfere in the signaling cascade regulated by this master oncogene.

The book covers topics ranging from basic RAS biology, to translational biology and drug discovery applications. These topics will be appealing to basic researchers working in labs who seek deeper understanding of the modern concepts in RAS research. On the other side, the oncologist at the patient’s bedside will find the book useful as they routinely face the daunting task of treating patients that predominantly have a disease driven by oncogenic KRAS.

Conquering RAS From Biology to Cancer Therapy 1st Table of contents:

Section 1. RAS Cancer Biology

• Chapter 1. Ras and RASSF Effector Proteins

• Chapter 2. Ras and the Hippo Pathway in Cancer

• Chapter 3. The Many Roles of Ral GTPases in Ras-Driven Cancer

• Chapter 4. The Biology, Prognostic Relevance, and Targeted Treatment of Ras Pathway–Positive Childhood Acute Lymphoblastic Leukemia

• Chapter 5. Oncogenic KRAS and the Inflammatory Micro-Environment in Pancreatic Cancer

• Chapter 6. Activation of Ras by Post-Translational Modifications

• Chapter 7. Cross Talk Between Snail and Mutant K-Ras Contributes to Pancreatic Cancer Progression

Section 2. Novel Therapeutic Approaches Targeting RAS and Related Pathways

• Chapter 8. Search for Inhibitors of Ras-Driven Cancers

• Chapter 9. GTP-Competitive Inhibitors of RAS Family Members

• Chapter 10. Next-Generation Strategies to Target RAF

• Chapter 11. Targeting Metabolic Vulnerabilities in RAS-Mutant Cells

• Chapter 12. Blocking SIAH Proteolysis, an Important K-RAS Vulnerability, to Control and Eradicate K-RAS-Driven Metastatic Cancer

• Chapter 13. Extracellular Signal-Regulated Kinase (ERK1 and ERK2) Inhibitors

• Chapter 14. Targeting Rho, Rac, CDC42 GTPase Effector p21 Activated Kinases in Mutant K-Ras-Driven Cancer

• Index

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