Pathophysiology of Disease: An Introduction to Clinical Medicine 7th Edition by Gary Hammer, Stephen McPhee ISBN 0071806016 9780071806015

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ISBN 10: 0071806016 
ISBN 13: 9780071806015
Author: Gary Hammer, Stephen McPhee

A full-color, case-based review of the essentials of pathophysiology–covering all major organs and systems The goal of this trusted text is to introduce you to clinical medicine by reviewing the pathophysiologic basis of 120 diseases (and associated signs and symptoms) commonly encountered in medical practice. The authors, all experts in their respective fields, have provided a concise review of relevant normal structure and function of each body system, followed by a description of the pathophysiologic mechanisms that underlie several common diseases related to that system. Each chapter of Pathophysiology of Disease concludes with a collection of case studies and questions designed to test your understanding of the pathophysiology of each clinical entity discussed. These case studies allow you to apply your knowledge to specific clinical situations. Detailed answers to each case study question are provided at the end of the book. This unique interweaving of physiological and pathological concepts will put you on the path toward thinking about signs and symptoms in terms of their pathophysiologic basis, giving you an understanding of the “why” behind illness and treatment. Features 120 case studies (9 new) provide an opportunity for you to test your understanding of the pathophysiology of each clinical entity discussed Checkpoint questions provide review and appear in every chapter Updates and revisions throughout this new edition reflect the latest research and developments Numerous tables and diagrams encapsulate important information Updated references for each chapter topic Pathophysiology of Disease is a true must-have resource for medical students preparing for the USMLE Step 1 exam, as well as students engaged in their clerkship studies. House officers, nurses, nurse practitioners, physicians’ assistants, and allied health practitioners will find its concise presentation and broad scope a great help in facilitating their understanding of common disease entities.

Pathophysiology of Disease: An Introduction to Clinical Medicine 7th Table of contents:

Section 1: Basic Mechanisms of Disease

1. The Cell and Its Response to Injury

   • Cellular Responses to Injury
   • Adaptation, Reversible, and Irreversible Injury
   • Cell Death: Apoptosis and Necrosis

2. Inflammation and Repair

   • Acute and Chronic Inflammation
   • Inflammatory Mediators and Pathways
   • Tissue Repair and Healing
   • Scar Formation and Fibrosis

3. The Immune System and Disease

   • Immune Response and Immunologic Disorders
   • Autoimmune Diseases
   • Hypersensitivity Reactions
   • Immunodeficiency States

4. Genetic Mechanisms of Disease

   • Molecular Genetics and Disease
   • Inherited Disorders
   • Genetic Mutations and Disease
   • Epigenetics and Disease

Section 2: Organ Systems and Disease

5. The Cardiovascular System

   • Pathophysiology of Atherosclerosis
   • Heart Failure and Cardiomyopathies
   • Hypertension and Its Consequences
   • Arrhythmias and Conduction Disorders
   • Valvular Heart Disease

6. The Respiratory System

   • Mechanisms of Airway Obstruction
   • Chronic Obstructive Pulmonary Disease (COPD)
   • Asthma and Allergic Disorders
   • Interstitial Lung Disease and Pneumonia
   • Pulmonary Hypertension

7. The Renal and Urologic Systems

   • Acute Kidney Injury and Chronic Renal Failure
   • Nephrotic and Nephritic Syndromes
   • Glomerulonephritis and Tubulointerstitial Disease
   • Urinary Tract Infections and Obstructive Uropathy
   • Renal Transplantation

8. The Gastrointestinal System

   • Acid-Base Imbalances and Digestion
   • Gastroesophageal Reflux Disease (GERD)
   • Inflammatory Bowel Disease (IBD)
   • Cirrhosis and Liver Failure
   • Pancreatitis and Hepatitis

9. The Endocrine System

   • Diabetes Mellitus: Type 1 and Type 2
   • Thyroid Disorders: Hyperthyroidism and Hypothyroidism
   • Adrenal Disorders and Cushing’s Syndrome
   • Disorders of the Parathyroid and Calcium Metabolism

10. The Nervous System

    • Mechanisms of Neuronal Injury
    • Cerebrovascular Disease and Stroke
    • Neurodegenerative Diseases (Parkinson’s, Alzheimer’s)
    • Seizures and Epilepsy
    • Brain Tumors and Neurological Infections

11. The Musculoskeletal System

    • Bone Disorders: Osteoporosis and Osteomalacia
    • Osteoarthritis and Rheumatoid Arthritis
    • Muscular Dystrophies and Myopathies
    • Tendon and Ligament Injuries

12. The Hematologic and Lymphatic Systems

    • Anemia and Hemoglobinopathies
    • Leukemia and Lymphoma
    • Hemostasis and Bleeding Disorders
    • Disorders of the Spleen

13. The Skin and Soft Tissues

    • Inflammatory and Infectious Skin Diseases
    • Dermatologic Manifestations of Systemic Disease
    • Neoplasms and Skin Cancer

Section 3: Special Topics

14. Cancer and Neoplasia

    • Tumor Biology and Carcinogenesis
    • Principles of Cancer Therapy
    • Cancer Syndromes and Genetic Predisposition

15. Infectious Disease and Pathophysiology

    • Mechanisms of Infectious Disease
    • Bacterial, Viral, Fungal, and Parasitic Infections
    • Host-Pathogen Interactions and Immune Response

16. Environmental and Occupational Medicine

    • Environmental Toxicology
    • Occupational Diseases and Injuries
    • Pathophysiology of Environmental Exposures

Section 4: Clinical Medicine and Disease Mechanisms

17. Clinical Manifestations of Disease

    • Symptoms and Signs in Clinical Practice
    • Differential Diagnosis
    • Diagnostic Testing and Imaging

18. Therapeutics and Disease Management

    • Pharmacology and Drug Mechanisms
    • Therapeutic Approaches to Disease Treatment
    • Surgery and Interventional Therapies

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