Phosphoinositide 3 kinase in Health and Disease Volume 2 1st Edition by Christian Rommel, Bart Vanhaesebroeck, Peter Vogt 3642148158 9783642148156

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ISBN 10: 3642148158

ISBN 13: 9783642148156

Author: Christian Rommel; ‎Bart Vanhaesebroeck; ‎Peter K. Vogt

PI3K has become a very intense area of research, with over 2000 publications on PI3K in PubMed for 2009 alone. The expectations for a therapeutic impact of intervention with PI3K activity are high, and progress in the clinical arena is being monitored by many. However, targeted therapies almost invariably encounter roadblocks, often exposing unresolved questions in the basic understanding of the target

Phosphoinositide 3 kinase in Health and Disease Volume 2 1st Table of contents:

PI3K: From the Bench to the Clinic and Back

Oncogenic Mutations of PIK3CA in Human Cancers

Structural Effects of Oncogenic PI3Kα Mutations

Comparing the Roles of the p110α and p110β Isoforms of PI3K in Signaling and Cancer

Phosphatidylinositol 3-Kinase: The Oncoprotein

AKT Signaling in Physiology and Disease

Faithfull Modeling of PTEN Loss Driven Diseases in the Mouse

PI3K as a Target for Therapy in Haematological Malignancies

Clinical Development of Phosphatidylinositol-3 Kinase Pathway Inhibitors

From the Bench to the Bed Side: PI3K Pathway Inhibitors in Clinical Development

New Inhibitors of the PI3K-Akt-mTOR Pathway: Insights into mTOR Signaling from a New Generation of Tor Kinase Domain Inhibitors (TORKinibs)

Small Molecule Inhibitors of the PI3-Kinase Family

Targeting the RTK-PI3K-mTOR Axis in Malignant Glioma: Overcoming Resistance

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