Bone Metastases A Translational and Clinical Approach 1st Edition by Dimitrios Kardamakis, ‎Vassilios Vassiliou, ‎Edward Chow 1402098189 9781402098185

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ISBN 10: 1402098189

ISBN 13: 9781402098185

Author: Dimitrios Kardamakis, ‎Vassilios Vassiliou, ‎Edward Chow

Bone Metastases: A Translational and Clinical Approach serves as both an introductory and reference book focusing on the field of metastatic bone disease. Featuring contributions from experts in the field, this volume: describes the molecular and cellular mechanisms involved in the formation of bone metastases, comments on the role of angiogenesis, presents the newer advances made in the understanding of the clinical picture and symptoms of patients, analyses the role of bone markers in research and clinical practice deals with all aspects of imaging modalities applied for the detection and evaluation of bone metastases. This volume also covers the use of radiotherapy, surgery and systemic treatments for the management of metastatic bone disease and new therapeutic approaches. Moreover it may also serve as a guide for the clinical and therapeutic management of patients with metastatic bone disease. Overall this volume presents a thorough overview of all aspects of metastatic bone disease and provides a comprehensive and concise information resource for medical researchers, oncologists, orthopaedic surgeons and clinicians.

Bone Metastases A Translational and Clinical Approach 1st Table of contents:

1. Fundamental Concepts

1. Pathophysiology of Bone Metastases

2. Natural History, Prognosis, Clinical Features and Complications of Metastatic Bone Disease

3. Pain in Bone Metastases: Types and Mechanisms

2. Investigations of Bone Metastases

4. Radiological Evaluations: Radiography, CT, MRI

5. Nuclear Medicine Imaging Modalities: Bone Scintigraphy, PET-CT, SPECT-CT

6. Bone Biomarkers in Research and Clinical Practice

7. The Application of ‘Omics’ Techniques for Cancers That Metastasise to Bone: From Biological Mechanism to Biomarkers

3. Therapeutic Management

8. Analgesic Treatment of Bone Metastases

9. External Beam Radiotherapy and Bone Metastases

10. Radionuclide Therapy

11. Bisphosphonates in Bone Metastatic Setting

12. New Targeted Therapies for Bone Metastases

13. Systemic Therapy of Bone Metastases

14. High-Intensity Focussed Ultrasound and Radio-Frequency Ablation for Bone Metastasis Treatment

15. Neuropathic Bone Metastases

16. Spinal Cord and Cauda Equina Compression

17. Pathological and Impending Fracture

18. Reirradiation

19. Challenges of Bone Metastases Treatment in Elderly Patients

20. Management of Metastatic Bone Disease in the Elderly with Bisphosphonates and RANKL Inhibitors: Effectiveness and Safety

4. Assessment of Therapeutic Response

21. Bone Metastases: Assessment of Therapeutic Response Using Radiological and Nuclear Medicine Imaging Modalities

22. Assessment of Therapeutic Response Through Clinical Assessment Measures

23. Outcome Measures in Bone Metastases Clinical Trials

24. Quality of Life in Patients Suffering from Metastatic Skeletal Disease

5. Cost of Managing Metastatic Bone Disease

25. Cost Effectiveness of Treatment Modalities for Bone Metastases

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