Biomarkers in Kidney Disease 1st Edition by Charles Edelstein ISBN 0123756723 9780123756725

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ISBN 10: 0123756723 
ISBN 13: 9780123756725
Author: Charles Edelstein

A biomarker is a molecule that is measured as a marker of normal biological processes, disease processes or the response to a diagnostic or therapeutic intervention. Kidney diseases like acute kidney injury, chronic kidney disease, diabetic nephropathy, glomerular disease, renal cancer and preeclampsia still have a high morbidity. Measurement of biomarkers in the blood or urine that detect patients at risk of kidney diseases or that detect kidney diseases in the earliest stage may ultimately result in preventative or earlier or more effective treatments for kidney diseases.

Biomarkers in Kidney Disease 1st Table of contents:

Chapter 1 Characteristics of an Ideal Biomarker of Kidney Diseases
1 The Discovery of Biomarkers
2 Characteristics of an Ideal Biomarker
3 Biomarkers in Acute Kidney Injury
4 Biomarkers in Chronic Kidney Disease
5 The Example of NGAL as a Biomarker of Acute Kidney Injury
References
Chapter 2 Statistical Considerations in Analysis and Interpretation of Biomarker Studies
1 Introduction
2 Planning a Study
3 Statistical Methods to Quantify Classification Performance
4 Sample Size Calculations
5 Emerging Methods
6 Summary
References
Chapter 3 The Role of Metabolomics in the Study of Kidney Diseases and in the Development of Diagnos
1 Introduction
2 Metabolic Mapping of the Kidney
3 Non-Targeted and Targeted Metabolomics
4 The Sample
5 Analytical Technologies
6 Metabolic Molecular Marker Discovery and Development
7 Metabolomics in Renal Research and as Kidney Function, Disease and Injury Marker
8 Metabolomics as Clinical Diagnostic Tool in Nephrology
References
Chapter 4 The Role of Proteomics in the Study of Kidney Diseases andnbspin the Development of Diagno
1 Introduction
2 Non-targeted and Targeted Proteomics
3 Proteins and the Kidney
4 The Proteomics Sample
5 Analytical Technologies
6 Proteomics in Renal Research and as a Marker for Kidney Function, Disease and Injury
7 Proteomics as Clinical Diagnostic Tool innbspNephrology
References
Chapter 5 Biomarkers in Acute Kidney Injury
1 Serum Creatinine in Acute Kidney Injury
2 Interleukin-18
3 Neutrophil Gelatinase-associated Lipocalin
4 Kidney Injury Molecule-1
5 Tubular Enzymes
6 Cystatin C
7 Other Biomarkers of Acute Kidney Injury
8 Combinations of AKI Biomarkers
9 Summary
10 Biomarkers of Extra-renal Complications of Acute Kidney Injury
References
Chapter 6 Biomarkers in Kidney Transplantation
1 Biomarkers: An Overview
2 Biomarkers of Acute Kidney Injury Post-transplantation (Table 6.1)
3 Biomarkers of Acute Rejection (Table 6.2)
4 Biomarkers of Chronic Allograft Nephropathy (Table 6.4)
5 Biomarkers of Polyoma Virus Infection
6 Summary
References
Chapter 7 Cystatin C as a Biomarker in Kidney Disease
1 Structure and Function of Cystatin C
2 Cystatin C Gene Structure and Cystatin C Production
3 Catabolism of Cystatin C
4 Cystatin C as a Marker for Glomerular Filtration Rate
5 Creatinine- and Cystatin C-based GFR-prediction Equations
6 The Lund Model: GFR-estimation with an Internal Quality Control
7 Abnormal Glomerular Filtration Quality: A New Marker for Kidney Disease. Use of Cystatin C to Iden
8 Cystatin C and Aging Success
References
Chapter 8 Biomarkers of Renal Cancer
1 Renal Cancer
2 Cancer Biomarkers – General Concepts
3 Renal Cancer Biomarkers
4 Conclusions
References
Chapter 9 Urinary Proteomics and Candidate Biomarker Discovery for Diabetic Nephropathy
1 Introduction
2 Urinary Proteins as Candidate Biomarkers of Diabetic Nephropathy
3 Urinary Peptides as Candidate Biomarkers of Type 2 Diabetic Nephropathy and Chronic Kidney Disease
4 Urinary Peptides as Candidate Biomarkers of Early Progressive Renal Function Declinenbspin Type 1
5 A Targeted Proteomic Analysis for Candidate Biomarkers of Early Renal Function Declinenbspin Type
6 Future Developments and Applications of Proteomics for Biomarker Discovery
References
Chapter 10 Biomarkers in Glomerular Disease
1 Biomarkers in Glomerular Diseases
2 Biomarkers in Lupus Nephritis
3 Membranous Nephropathy
4 Focal Segmental Glomerulosclerosis
5 Minimal Change Disease
6 IgA Nephropathy
7 ANCA-associated Vasculitis
8 Discovery of New Biomarkers using Proteomics
References
Chapter 11 Biomarkers in Preeclampsia
1 Definition and Prevalence of the Disease
2 Pathophysiology and Mechanisms
3 Clinical Manifestations
4 Diagnosis
5 Biomarkers
6 Novel Biomarkers and Future Perspectives
7 Conclusion

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